Synthesis and anti-microbial activity of a new series of bis(diphosphine) rhenium(v) dioxo complexes†
Saul M.
Cooper, 
a
Christina
Siakalli,
a
Andrew J. P.
White,
a
Angelo
Frei,
a
Philip W.
Miller
*a
and
Nicholas J.
Long
*a
a
Christina
Siakalli,
a
Andrew J. P.
White,
a
Angelo
Frei,
a
Philip W.
Miller
*a
and
Nicholas J.
Long
*a
Abstract
Rhenium-based metallodrugs have recently been highlighted as promising candidates for new antibiotics to combat multi-drug resistant (MDR) pathogens. A new class of rhenium(V) dioxo complexes were prepared from readily accessible diphosphine ligands, and have been shown to possess potent activity against Staphylococcus aureus (S. aureus) and Candida albicans (C. albicans) alongside low human cell toxicity.
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