Stability of a half-sandwich Os(II) complex with indomethacin-functionalized ligand in the presence of carboxypeptidase A

Lukáš Masaryk; Darina Muthná; Petr Halaš; Pavel Zoufalý; Eva Peterová; Radim Havelek; Bohuslav Drahoš; David Milde; Alena Mrkvicová; Pavel Štarha

doi:10.1039/D2DT01085B

Stability of a half-sandwich Os(ii) complex with indomethacin-functionalized ligand in the presence of carboxypeptidase A†

Lukáš Masaryk,^a Darina Muthná,^b Petr Halaš,^a Pavel Zoufalý,^a Eva Peterová,^b Radim Havelek,

^b Bohuslav Drahoš,

^a David Milde,

^c Alena Mrkvicová^b and Pavel Štarha

*^a

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^a Department of Inorganic Chemistry, Faculty of Science, Palacky University in Olomouc, 17. listopadu 12, 77146 Olomouc, Czech Republic
E-mail: pavel.starha@upol.cz
Tel: +420 585 634 348

^b Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Šimkova 870, 500 03 Hradec Kralove, Czech Republic

^c Department of Analytical Chemistry, Faculty of Science, Palacký University in Olomouc, 17. listopadu 12, 771 46 Olomouc, Czech Republic

Abstract

In the presence of carboxypeptidase, the hydrolytically stable complex [Os(η⁶-pcym)(L2)Cl]PF₆ (2) partially released the bioactive substituent indomethacin, bound through the amide bond to the chelating 2-(1,3,4-thiadiazol-2-yl)pyridine-based moiety of L2. Stability in the presence of other relevant biomolecules (GSH, NADH, GMP) and cancer cell viability were also studied.

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Stability of a half-sandwich Os(ii) complex with indomethacin-functionalized ligand in the presence of carboxypeptidase A†

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Stability of a half-sandwich Os(II) complex with indomethacin-functionalized ligand in the presence of carboxypeptidase A

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