Co-crystals of zwitterionic GABA API's pregabalin and phenibut: properties and application

Abstract

We present several multicomponent crystalline species formed by zwitterionic GABA analogues pregabalin and phenibut. These compounds are evaluated based on their crystal structure in congruence with properties such as melting behaviour, solubility, and lattice energies. Furthermore, it is discussed how major property distinctions between a homo- and heterochiral co-crystalline system enable enantiopurification of pregabalin.