Issue 35, 2022

Transforming liquid nicotine into a stable solid through crystallization with orotic acid

Abstract

Many molecular drugs exist as liquid materials, however this state is not necessarily the most viable or stable means to store pharmaceuticals. Crystal engineering can be utilized to isolate these liquid materials in the solid state. Herein, we describe the liquid-state to solid-state transformation of one of the most widely consumed liquid alkaloid drugs; nicotine. Nicotine is known to be highly unstable with a multitude of degradation pathways. To isolate nicotine in the solid-state, crystallization was utilized with the generally recognized as safe (GRAS) salt former orotic acid. The melting point of the isolated crystalline salt was determined along with the photo-stabilizing effects the solid state offers for liquid pharmaceuticals such as nicotine.

Graphical abstract: Transforming liquid nicotine into a stable solid through crystallization with orotic acid

Supplementary files

Article information

Article type
Paper
Submitted
03 Jun 2022
Accepted
27 Jul 2022
First published
01 Aug 2022

CrystEngComm, 2022,24, 6155-6164

Transforming liquid nicotine into a stable solid through crystallization with orotic acid

D. J. Angevine, K. J. Camacho, J. Rzayev and J. B. Benedict, CrystEngComm, 2022, 24, 6155 DOI: 10.1039/D2CE00764A

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