Issue 100, 2022

Expedient delivery of quinolinone drugs via a traceless N-nitroso enabled oxidative Heck/amidation cascade

Abstract

The exploration of green C–H oxidation for the rapid construction of functional molecules, remains a permanent goal in synthetic chemistry. Herein, a traceless N-nitroso enabled oxidative Heck and amidation cascade was realized, leading to quinolinones that feature green oxidation and great functional group tolerance. The expedient construction of quinolinone containing pharmaceuticals including Flucarbril, Clostamide and Aripiprazole was achieved in a concise and environmentally friendly manner.

Graphical abstract: Expedient delivery of quinolinone drugs via a traceless N-nitroso enabled oxidative Heck/amidation cascade

Supplementary files

Article information

Article type
Communication
Submitted
10 Oct 2022
Accepted
11 Nov 2022
First published
14 Nov 2022

Chem. Commun., 2022,58, 13959-13962

Expedient delivery of quinolinone drugs via a traceless N-nitroso enabled oxidative Heck/amidation cascade

Z. Li, X. Chen, H. Zhong, Y. Lin, Y. Gao, Y. Liu, Q. Chen, Y. Huo and X. Li, Chem. Commun., 2022, 58, 13959 DOI: 10.1039/D2CC05514G

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