Dinuclear osmium complexes as mitochondrion-targeting antitumor photothermal agents in vivo

Meng-Fan Wang; Yu-Ang Deng; Qing-Fang Li; Shi-Jie Tang; Rong Yang; Run-Yu Zhao; Fu-Dan Liu; Xiaoxia Ren; Dan Zhang; Feng Gao

doi:10.1039/D2CC05230J

Dinuclear osmium complexes as mitochondrion-targeting antitumor photothermal agents in vivo†

Meng-Fan Wang,^a Yu-Ang Deng,^a Qing-Fang Li,^a Shi-Jie Tang,^a Rong Yang,^a Run-Yu Zhao,^a Fu-Dan Liu,^a Xiaoxia Ren,^b Dan Zhang^c and Feng Gao

*^a

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* Corresponding authors

^a Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Pharmacy, Yunnan University, Kunming, 650091, P. R. China
E-mail: gaofeng@ynu.edu.cn

^b Animal Research and Resource Center, School of Life Sciences, Yunnan University, Kunming, 650091, P. R. China

^c First Affiliated Hospital of Kunming Medical University, Kunming 650032, P. R. China

Abstract

Four dinuclear osmium complexes have been constructed for antitumor phototherapy. The most potent Os4 has extremely high photothermal conversion capability under irradiation of an 808 nm low-power laser, targets mitochondria in human melanoma cells without nucleus affinity, and acts as an antitumor photothermal therapy agent in vitro and in vivo.

Chemical Communications

Dinuclear osmium complexes as mitochondrion-targeting antitumor photothermal agents in vivo†

Abstract

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Dinuclear osmium complexes as mitochondrion-targeting antitumor photothermal agents in vivo

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