Issue 97, 2022
From the journal:

Chemical Communications

A general nickel-catalyzed highly regioselective hydroarylation of unactivated alkenes enabled by the picolinamide auxiliary†

Lanlan Zhang,a   Chun Luo,a   Haoran Shi,a   Lin Zhu,a   Yuan-Qing Xu,b   Zhong-Yan Cao ORCID logo *b  and  Chao Wang ORCID logo *a  

* Corresponding authors

a Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, China
E-mail: chwang@tjnu.edu.cn

b College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China
E-mail: zycao@henu.edu.cn

Abstract

A practical method for regioselective hydroarylation of unactivated γ- or δ-vinyl alkylamines has been reported, enabling facile preparation of highly value-added ε- or ζ-aryl alkylamines. The protocol employs nickel catalysis, shows high functional group tolerance and can be used for modifying bio-related molecules.

Graphical abstract: A general nickel-catalyzed highly regioselective hydroarylation of unactivated alkenes enabled by the picolinamide auxiliary

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Article information

DOI
https://doi.org/10.1039/D2CC04932E
Article type
Communication
Submitted
06 Sep 2022
Accepted
10 Nov 2022
First published
10 Nov 2022

Chem. Commun., 2022,58, 13511-13514

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A general nickel-catalyzed highly regioselective hydroarylation of unactivated alkenes enabled by the picolinamide auxiliary

L. Zhang, C. Luo, H. Shi, L. Zhu, Y. Xu, Z. Cao and C. Wang, Chem. Commun., 2022, 58, 13511 DOI: 10.1039/D2CC04932E

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