Issue 87, 2022

Chemical tools to track and perturb the expression of sialic acid and fucose monosaccharides

Abstract

The biosynthesis of glycans is a highly conserved biological process and found in all domains of life. The expression of cell surface glycans is increasingly recognized as a target for therapeutic intervention given the role of glycans in major pathologies such as cancer and microbial infection. Herein, we summarize our contributions to the development of unnatural monosaccharide derivatives to infiltrate and alter the expression of both mammalian and bacterial glycans and their therapeutic application.

Graphical abstract: Chemical tools to track and perturb the expression of sialic acid and fucose monosaccharides

Article information

Article type
Feature Article
Submitted
31 Jul 2022
Accepted
05 Oct 2022
First published
10 Oct 2022
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2022,58, 12139-12150

Chemical tools to track and perturb the expression of sialic acid and fucose monosaccharides

E. Rossing, J. F. A. Pijnenborg and T. J. Boltje, Chem. Commun., 2022, 58, 12139 DOI: 10.1039/D2CC04275D

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