Site-specific unnatural base excision via visible light

Yuan-Yang Guo; Rujie Zhang; Bianbian Huo; Luying Wang; Donghe Yuan; Jingsi Bai; Honglei Wang; Gongming Zhu; Xiguang Zhang; Anlian Zhu; Tingjian Chen; Lingjun Li

doi:10.1039/D2CC03664A

Site-specific unnatural base excision via visible light†

Yuan-Yang Guo,

‡^a Rujie Zhang,‡^b Bianbian Huo,‡^a Luying Wang,^a Donghe Yuan,^a Jingsi Bai,^b Honglei Wang,^a Gongming Zhu,^a Xiguang Zhang,^a Anlian Zhu,

^a Tingjian Chen

*^b and Lingjun Li

*^a

Author affiliations

* Corresponding authors

^a Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Xinxiang, Henan 453007, China
E-mail: lingjunlee@htu.edu.cn

^b MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, P. R. China
E-mail: chentj@scut.edu.cn

Abstract

Base excision (BE) is an important yet hard-to-control biological event. Unnatural base pairs are powerful tools to revolutionize biological studies in various areas. In this paper, we report a visible-light-induced method to construct site-specific unnatural BE and show the influence of its regulation on transcription and translation levels.

Chemical Communications

Site-specific unnatural base excision via visible light†

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Site-specific unnatural base excision via visible light

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