Enantioselective C–H bond functionalization of aromatic ketones with 1,6-enynes via photoredox/cobalt dual catalysis

Abstract

An enantioselective ortho-C(sp2)–H functionalization of ketones with 1,6-enynes is demonstrated via photoredox/cobalt dual catalysis. The method exhibits high yields, functional group tolerance, and selectivity. Mechanistic studies suggested the operation of visible-light mediated low-valent cobalt complex generation, intramolecular cyclization, ortho-C–H bond insertion, and reductive elimination as the key mechanistic steps.

Graphical abstract: Enantioselective C–H bond functionalization of aromatic ketones with 1,6-enynes via photoredox/cobalt dual catalysis

Supplementary files

Article information

Article type
Communication
Submitted
28 Jun 2022
Accepted
22 Jul 2022
First published
22 Jul 2022

Chem. Commun., 2022, Advance Article

Enantioselective C–H bond functionalization of aromatic ketones with 1,6-enynes via photoredox/cobalt dual catalysis

K. Maji, P. R. Thorve, P. Rai and B. Maji, Chem. Commun., 2022, Advance Article , DOI: 10.1039/D2CC03595B

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