Issue 66, 2022
From the journal:

Chemical Communications

Palladium(ii)-catalyzed enantioselective intermolecular oxidative diarylation of internal enamides†

Tingting Xia,a   Yang Xi,a   Haojie Ding,a   Yetong Zhang,a   Ke Fang,a   Xianqing Wu,a   Jingping Qu ORCID logo a  and  Yifeng Chen ORCID logo *a  

* Corresponding authors

a Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, China
E-mail: yifengchen@ecust.edu.cn

Abstract

The construction of vicinal stereogenic centers via the simultaneous formation of two C–C bonds across alkenes under oxidative conditions is a stubborn challenge. Herein, we report a Pd(II)-catalyzed highly enantioselective intermolecular oxidative 1,2-diarylation reaction of internal enamides with aryl boronic acids, enabling the expedient construction of two vicinal stereocenters with excellent diastereo-, and enantioselectivities.

Graphical abstract: Palladium(ii)-catalyzed enantioselective intermolecular oxidative diarylation of internal enamides

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Article information

DOI
https://doi.org/10.1039/D2CC03202C
Article type
Communication
Submitted
07 Jun 2022
Accepted
20 Jul 2022
First published
25 Jul 2022

Chem. Commun., 2022,58, 9282-9285

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Palladium(II)-catalyzed enantioselective intermolecular oxidative diarylation of internal enamides

T. Xia, Y. Xi, H. Ding, Y. Zhang, K. Fang, X. Wu, J. Qu and Y. Chen, Chem. Commun., 2022, 58, 9282 DOI: 10.1039/D2CC03202C

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