Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

James P. C. Coverdale; Hugo A. van den Berg; Siavash Khazaipoul; Hannah E. Bridgewater; Alan J. Stewart; Claudia A. Blindauer

doi:10.1039/D2CC02278H

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Albumin-mediated extracellular zinc speciation drives cellular zinc uptake†

James P. C. Coverdale,

^ab Hugo A. van den Berg,

^c Siavash Khazaipoul,^d Hannah E. Bridgewater,

^a Alan J. Stewart

^d and Claudia A. Blindauer

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Warwick, Coventry, UK
E-mail: c.blindauer@warwick.ac.uk

^b School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Edgbaston, UK

^c Warwick Mathematics Institute, University of Warwick, Coventry, UK

^d School of Medicine, University of St. Andrews, St. Andrews, UK

Abstract

The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.

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Article information

DOI: https://doi.org/10.1039/D2CC02278H
Article type: Communication
Submitted: 21 Apr 2022
Accepted: 26 May 2022
First published: 02 Jun 2022
This article is Open Access

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Chem. Commun., 2022,58, 7384-7387

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Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

J. P. C. Coverdale, H. A. van den Berg, S. Khazaipoul, H. E. Bridgewater, A. J. Stewart and C. A. Blindauer, Chem. Commun., 2022, 58, 7384 DOI: 10.1039/D2CC02278H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Chemical Communications

Albumin-mediated extracellular zinc speciation drives cellular zinc uptake†

Abstract

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Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

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