Issue 32, 2022
From the journal:

Chemical Communications

An antioxidant boehmite amino-nanozyme able to disaggregate Huntington's inclusion bodies†

Álvaro Martínez-Camarena, ORCID logo *a   Marian Merino,b   Ana Virginia Sánchez-Sánchez,b   Salvador Blasco, ORCID logo a   José M. Llinares, ORCID logo c   José L. Mullorb  and  Enrique García-España ORCID logo *a  

* Corresponding authors

a ICMol, Departamento de Química Inorgánica, University of Valencia, C/Catedrático José Beltrán 2, Paterna, Spain
E-mail: alvaro.martinez@uv.es, enrique.garcia-es@uv.es

b Bionos Biotech SL, Biopolo La Fe, IIS La Fe, Av. Fernando Abril Martorell, Torre 106 A 7 planta, 46026 València, Spain

c Departamento de Química Orgánica, University of Valencia, C/Dr Moliner s/n, Burjassot, Spain

Abstract

A novel amino-nanozyme, based on boehmite nanoparticles (BNPs) functionalised with a tetra-azapyridinophane (L1), has been designed to undermine some of the key issues underlying Huntington disease. L1 forms Cu2+ complexes with a striking SOD activity, while when grafted to the BNPs displays mitoROS scavenging properties and ability to disaggregate mutant huntingtin deposits in cells.

Graphical abstract: An antioxidant boehmite amino-nanozyme able to disaggregate Huntington's inclusion bodies

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Article information

DOI
https://doi.org/10.1039/D2CC01257J
Article type
Communication
Submitted
01 Mar 2022
Accepted
28 Mar 2022
First published
30 Mar 2022

Chem. Commun., 2022,58, 5021-5024

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An antioxidant boehmite amino-nanozyme able to disaggregate Huntington's inclusion bodies

Á. Martínez-Camarena, M. Merino, A. V. Sánchez-Sánchez, S. Blasco, J. M. Llinares, J. L. Mullor and E. García-España, Chem. Commun., 2022, 58, 5021 DOI: 10.1039/D2CC01257J

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