Issue 33, 2022
From the journal:

Chemical Communications

Stabilization of bicelles using metal-binding peptide for extended blood circulation†

Yuichiro Takagi,a   Noriyuki Uchida, ORCID logo *a   Yasutaka Anrakubc  and  Takahiro Muraoka ORCID logo *ade  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan
E-mail: n-uchida@go.tuat.ac.jp, muraoka@go.tuat.ac.jp

b Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

c Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, 3-25-14, Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan

d Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 3-8-1 Harumi-cho, Fuchu-Shi, Tokyo 183-8538, Japan

e Kanagawa Institute of Industrial Science and Technology (KISTEC), 705-1 Shimoimaizumi, Ebina, Kanagawa 243-0435, Japan

Abstract

A metal-binding peptide appending cholic acid, Chol-MBP, formed bicelles by mixing with 1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine (DPPC). Coordination of Chol-MBP with Cu2+ stabilized DPPC bicelles against dilution and contamination of serum proteins, enabling extended blood circulation. This study demonstrates an effective supramolecular design of phospholipid bicelles with enhanced stability useful for membrane-based biomaterials.

Graphical abstract: Stabilization of bicelles using metal-binding peptide for extended blood circulation

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Article information

DOI
https://doi.org/10.1039/D2CC01058E
Article type
Communication
Submitted
21 Feb 2022
Accepted
30 Mar 2022
First published
31 Mar 2022

Chem. Commun., 2022,58, 5164-5167

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Stabilization of bicelles using metal-binding peptide for extended blood circulation

Y. Takagi, N. Uchida, Y. Anraku and T. Muraoka, Chem. Commun., 2022, 58, 5164 DOI: 10.1039/D2CC01058E

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