Issue 33, 2022

Stabilization of bicelles using metal-binding peptide for extended blood circulation

Abstract

A metal-binding peptide appending cholic acid, Chol-MBP, formed bicelles by mixing with 1,2-dipalmitoyl-sn-glycero-3-phosphorylcholine (DPPC). Coordination of Chol-MBP with Cu2+ stabilized DPPC bicelles against dilution and contamination of serum proteins, enabling extended blood circulation. This study demonstrates an effective supramolecular design of phospholipid bicelles with enhanced stability useful for membrane-based biomaterials.

Graphical abstract: Stabilization of bicelles using metal-binding peptide for extended blood circulation

Supplementary files

Article information

Article type
Communication
Submitted
21 Feb 2022
Accepted
30 Mar 2022
First published
31 Mar 2022

Chem. Commun., 2022,58, 5164-5167

Stabilization of bicelles using metal-binding peptide for extended blood circulation

Y. Takagi, N. Uchida, Y. Anraku and T. Muraoka, Chem. Commun., 2022, 58, 5164 DOI: 10.1039/D2CC01058E

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