Issue 26, 2022

Programmable iodization/deuterolysis sequences of phosphonium ylides to access deuterated benzyl iodides and aromatic aldehydes

Abstract

Herein, a tunable iodization/deuterolysis protocol for phosphonium ylides by employing D2O as the deuterium source was designed. Notably, this process could be manipulated by tuning the base, thus leading to two valuable deuterated building blocks – benzyl iodides and aromatic aldehydes with broad substrate scope, good functional group compatibility and excellent deuteration degree. Concise syntheses of a series of deuterated drug analogues have been achieved based on the developed deuteration reaction platform.

Graphical abstract: Programmable iodization/deuterolysis sequences of phosphonium ylides to access deuterated benzyl iodides and aromatic aldehydes

Supplementary files

Article information

Article type
Communication
Submitted
26 Jan 2022
Accepted
04 Mar 2022
First published
06 Mar 2022

Chem. Commun., 2022,58, 4215-4218

Programmable iodization/deuterolysis sequences of phosphonium ylides to access deuterated benzyl iodides and aromatic aldehydes

Y. Zheng, X. He, J. Gao, Z. Xie, Z. Wang, Z. Liu, K. Chen, H. Xiang, X. Chen and H. Yang, Chem. Commun., 2022, 58, 4215 DOI: 10.1039/D2CC00537A

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