In situ fluorescence imaging reveals that mitochondrial H2O2 mediates lysosomal dysfunction in depression†
Abstract
We constructed two fluorescent probes for monitoring H2O2 in the mitochondria and lysosomes. Fluorescence imaging reveals that mitochondrial H2O2 mediates reduced GCase activity in lysosomes in the brains of mice with depression. This work provides a powerful tool for understanding the pathogenesis of depression.