Issue 19, 2022

Anhydrous calcium phosphate crystals stabilize DNA for dry storage

Abstract

The resilience of ancient DNA (aDNA) in bone gives rise to the preservation of synthetic DNA with bioinorganic materials such as calcium phosphate (CaP). Accelerated aging experiments at elevated temperature and humidity displayed a positive effect of co-precipitated, crystalline dicalcium phosphate on the stability of synthetic DNA in contrast to amorphous CaP. Quantitative PXRD in combination with SEM and EDX measurements revealed distinct CaP phase transformations of calcium phosphate dihydrate (brushite) to anhydrous dicalcium phosphate (monetite) influencing DNA stability.

Graphical abstract: Anhydrous calcium phosphate crystals stabilize DNA for dry storage

Supplementary files

Article information

Article type
Communication
Submitted
21 Jan 2022
Accepted
07 Feb 2022
First published
07 Feb 2022
This article is Open Access
Creative Commons BY license

Chem. Commun., 2022,58, 3174-3177

Anhydrous calcium phosphate crystals stabilize DNA for dry storage

P. L. Antkowiak, J. Koch, P. Rzepka, B. H. Nguyen, K. Strauss, W. J. Stark and R. N. Grass, Chem. Commun., 2022, 58, 3174 DOI: 10.1039/D2CC00414C

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