Issue 11, 2022

Cell-penetrating poly(disulfide)-based nanoquenchers (qCPDs) for self-monitoring of intracellular gene delivery

Abstract

Monitoring gene delivery has significant benefits in gene therapy. Herein, we report a nanoquencher system by doping a FRET pair during nucleic acid-assisted cell penetrating poly(disulfide) (CPD) formation. Our results show that this strategy not only produces an efficient gene delivery polymer with minimal endolysosomal trapping, but also enables monitoring the release of the gene from the vehicle in live cells. This study further expanded the application of CPDs as promising tools in gene delivery.

Graphical abstract: Cell-penetrating poly(disulfide)-based nanoquenchers (qCPDs) for self-monitoring of intracellular gene delivery

Supplementary files

Article information

Article type
Communication
Submitted
14 Dec 2021
Accepted
30 Dec 2021
First published
31 Dec 2021

Chem. Commun., 2022,58, 1792-1795

Cell-penetrating poly(disulfide)-based nanoquenchers (qCPDs) for self-monitoring of intracellular gene delivery

W. Lang, S. S. Liew, S. Wang, D. Hong, L. Zhu, S. Du, L. Jiang, S. Q. Yao and J. Ge, Chem. Commun., 2022, 58, 1792 DOI: 10.1039/D1CC07020G

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