Issue 2, 2022

Hypocrellin B-based activatable photosensitizers for specific photodynamic effects against high H2O2-expressing cancer cells

Abstract

A novel tumor-related biomarker, a H2O2-activatable photosensitizer 4 based on the 1,3-dicarbonyl enol moieties of hypocrellin B (3), was designed and synthesized. The photosensitizer 4 showed a blue-shifted absorption band compared with 3, and showed negligible photosensitizing ability without H2O2. However, the release of 3 from 4 by the reaction with H2O2 regenerated the photosensitizing ability. Furthermore, 4 exhibited selective and effective photo-cytotoxicity against high H2O2-expressing cancer cells upon photo-irradiation with 660 nm light, which is inside the phototherapeutic window.

Graphical abstract: Hypocrellin B-based activatable photosensitizers for specific photodynamic effects against high H2O2-expressing cancer cells

Supplementary files

Article information

Article type
Communication
Submitted
15 Oct 2021
Accepted
20 Nov 2021
First published
22 Nov 2021

Chem. Commun., 2022,58, 242-245

Hypocrellin B-based activatable photosensitizers for specific photodynamic effects against high H2O2-expressing cancer cells

T. Kitamura, H. Nakata, D. Takahashi and K. Toshima, Chem. Commun., 2022, 58, 242 DOI: 10.1039/D1CC05823A

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