Issue 11, 2022

Combining bio- and organocatalysis for the synthesis of piperidine alkaloids

Abstract

There is continued interest in developing cascade processes for the synthesis of key chiral building blocks and bioactive natural products (or analogues). Here, we report a hybrid bio–organocatalytic cascade for the synthesis of a small panel of 2-substituted piperidines, relying on a transaminase to generate a key reactive intermediate for the complexity building Mannich reaction.

Graphical abstract: Combining bio- and organocatalysis for the synthesis of piperidine alkaloids

Supplementary files

Article information

Article type
Communication
Submitted
16 Jul 2021
Accepted
24 Dec 2021
First published
30 Dec 2021

Chem. Commun., 2022,58, 1697-1700

Combining bio- and organocatalysis for the synthesis of piperidine alkaloids

F. Taday, R. Cairns, A. O’Connell and E. O’Reilly, Chem. Commun., 2022, 58, 1697 DOI: 10.1039/D1CC03865F

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