Facile room temperature synthesis of a NiFe2O4-based magnetic covalent organic framework for the extraction of tetracycline residues in environmental water samples prior to HPLC

Abstract

In this study, a functionalized magnetic covalent organic framework (NiFe₂O₄@TAPB-TPA) was fabricated with NiFe₂O₄ nanoparticles as the magnetic core, and 1,3,5-tris(4-aminophenyl)benzene (TAPB) and terephthalaldehyde (TPA) as building blocks by a facile room temperature strategy. Benefitting from the π–π stacking and hydrogen bond interaction, NiFe₂O₄@TAPB-TPA showed great potential as a magnetic adsorbent for the extraction of tetracyclines (TCs). Under optimal conditions, good linearities (R² > 0.9990) were obtained between the peak area and TC concentration in the range of 1–500 μg L⁻¹ with limits of detection ranging from 0.09 to 0.26 μg L⁻¹. The intra-day and inter-day relative standard deviations were less than 2.2% and 4.7%, respectively. The established method was successfully applied for the determination of TCs in diverse environmental water samples with satisfactory recoveries in the range of 91.6–102.7%. In addition, NiFe₂O₄@TAPB-TPA showed good reusability with the recoveries for TCs higher than 73.1% after nine recycles, indicating potential application of NiFe₂O₄@TAPB-TPA as an ideal adsorbent for the enrichment of TCs.