Discrimination of commercial ibuprofen tablets by using a button sample holder and mid-infrared spectroscopy

Abstract

Infrared spectra obtained from commercial ibuprofen tablets are categorized by using principal component analysis. A stainless steel abrasive button is used to sample the coatings and interiors of ibuprofen tablets with three different formulations. Rubbing the button wire mesh surface across tablet surfaces removes material for analysis. Small fragments are retained within mesh void spaces and larger fragments are swept away prior to analyses. Infrared spectra for tablet coatings exhibit significant differences and can be used for identification. Tablet interior compositions consisting primarily of ibuprofen from different manufacturers are more distinguishable from pre-processed spectra than from spectrum second derivatives. The speed and sensitivity afforded by this methodology suggests that rapid detection of counterfeit pharmaceuticals based on mid-infrared spectroscopy measurements of microgram quantities of material removed with a button sample holder is feasible.