Issue 45, 2022

Direct routes to functional RAFT agents from substituted N-alkyl maleimides

Abstract

N-substituted maleimides have become an indispensable tool for the synthesis of bioconjugates and functional materials. Herein, we present three strategies for the incorporation of N-alkyl substituted maleimides into RAFT agents and show that these maleimide-derived CTAs can be used to easily introduce a range of chemical functionality at the β-position of polymer chains, resulting in α,β,ω-functional RAFT polymers. With both functional maleimides and RAFT agents that are increasingly available on the market, the approach presented in this study could facilitate the synthesis of end-functional macromolecules and will complement well the range of existing synthetic routes, including those utilising N-substituted maleimides, to functional polymeric materials.

Graphical abstract: Direct routes to functional RAFT agents from substituted N-alkyl maleimides

Supplementary files

Article information

Article type
Communication
Submitted
23 Nov 2021
Accepted
26 Oct 2022
First published
14 Nov 2022
This article is Open Access
Creative Commons BY license

Polym. Chem., 2022,13, 6261-6267

Direct routes to functional RAFT agents from substituted N-alkyl maleimides

R. Catania, R. Foralosso, L. Spanos, E. Russo, F. Mastrotto, P. Gurnani, K. Butler, H. Williams, S. Stolnik and G. Mantovani, Polym. Chem., 2022, 13, 6261 DOI: 10.1039/D1PY01565F

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