Issue 3, 2022
From the journal:

Polymer Chemistry

Assembly of catechol-modified polymer brushes for drug delivery†

Kaijie Zhao, ORCID logo a   Zhiliang Gao, ORCID logo a   Dongpo Song,*b   Peiyu Zhang ORCID logo *a  and  Jiwei Cui ORCID logo *ac  

* Corresponding authors

a Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China
E-mail: pyzhang@sdu.edu.cn, jwcui@sdu.edu.cn

b Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin 300350, China
E-mail: dongpo.song@tju.edu.cn

c State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong 266237, China

Abstract

Therapeutic nanoparticles (NPs) have shown their potential for biomedical applications (e.g., drug delivery). In this study, we report the synthesis of a bottlebrush block copolymer by ring opening metathesis polymerization (ROMP) and fabrication of pH-responsive NPs (denoted as BNPs) by self-assembly of an innovative bortezomib (BTZ) prodrug. The cleavage of borate ester bonds at acidic pH results in the release of BTZ from BNPs. Moreover, BNPs can inhibit cell and tumor growth without significant side effects.

Graphical abstract: Assembly of catechol-modified polymer brushes for drug delivery

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Article information

DOI
https://doi.org/10.1039/D1PY00947H
Article type
Communication
Submitted
13 Jul 2021
Accepted
13 Dec 2021
First published
16 Dec 2021

Polym. Chem., 2022,13, 373-378

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Assembly of catechol-modified polymer brushes for drug delivery

K. Zhao, Z. Gao, D. Song, P. Zhang and J. Cui, Polym. Chem., 2022, 13, 373 DOI: 10.1039/D1PY00947H

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