Issue 27, 2022

SABRE enhancement with oscillating pulse sequences

Abstract

SABRE (Signal Amplification by Reversible Exchange) methods provide a simple, fast, and cost-effective method to hyperpolarize a wide variety of molecules in solution, and have been demonstrated with protons and, more recently, with heteronuclei (X-SABRE). Here, we present several oscillating pulse sequences that use magnetic fields far away from the resonance condition of continuous excitation and can commonly triple the polarization. An analysis with average Hamiltonian theory indicates that the oscillating pulse, in effect, adjusts the J-couplings between hydrides and target nuclei and that a much weaker coupling produces maximum polarization. This theoretical treatment, combined with simulations and experiment, shows substantial magnetization improvements relative to traditional X-SABRE methods. It also shows that, in contrast to most pulse sequence applications, waveforms with reduced time symmetry in the toggling frame make magnetization generation more robust to experimental imperfections.

Graphical abstract: SABRE enhancement with oscillating pulse sequences

Supplementary files

Article information

Article type
Paper
Submitted
23 Feb 2022
Accepted
04 May 2022
First published
09 May 2022

Phys. Chem. Chem. Phys., 2022,24, 16462-16470

SABRE enhancement with oscillating pulse sequences

X. Li, J. R. Lindale, S. L. Eriksson and W. S. Warren, Phys. Chem. Chem. Phys., 2022, 24, 16462 DOI: 10.1039/D2CP00899H

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