Issue 78, 2022
From the journal:

Chemical Communications

SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy†

Yoon Kyung Park,‡a   Paramesh Jangili,‡b   Soyu Zi, ORCID logo b   Rae Hyung Kang,*c   Dokyoung Kim ORCID logo *acdef  and  Jong Seung Kim ORCID logo *b  

* Corresponding authors

a Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea
E-mail: dkim@khu.ac.kr

b Department of Chemistry, Korea University, Seoul 02841, Republic of Korea
E-mail: jongskim@korea.ac.kr

c Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea
E-mail: hpohpo2000@khu.ac.kr

d KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Republic of Korea

e Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea

f Center for Converging Humanities, Kyung Hee University, Seoul 02447, Republic of Korea

Abstract

A new conjugate formulation, SIWV-PB-SN, based on glioblastoma (GBM)-homing SIWV tetrapeptide and an ROS-responsive prodrug is reported. SIWV-PB-SN selectively penetrates the GBM cells and releases anti-GBM drug (SN-38) via ROS-induced linker cleavage. This study presents a new insight for a more advanced therapeutic approach to overcoming GBM.

Graphical abstract: SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy

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Article information

DOI
https://doi.org/10.1039/D2CC03777G
Article type
Communication
Submitted
07 Jul 2022
Accepted
01 Sep 2022
First published
09 Sep 2022

Chem. Commun., 2022,58, 10941-10944

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SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy

Y. K. Park, P. Jangili, S. Zi, R. H. Kang, D. Kim and J. S. Kim, Chem. Commun., 2022, 58, 10941 DOI: 10.1039/D2CC03777G

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