Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide

Abstract

Non-canonical DNA structures, particularly 3-Way Junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core.

Graphical abstract: Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide

Supplementary files

Article information

Article type
Communication
Submitted
20 May 2022
Accepted
15 Jun 2022
First published
22 Jun 2022

Chem. Commun., 2022, Advance Article

Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide

J. Gómez-González, L. Martínez-Castro, J. Tolosa-Barrilero, A. Alcalde-Ordóñez, S. Learte-Aymamí, J. L. Mascareñas, J. C. García-Martínez, J. Martínez-Costas, J. Maréchal, M. Vázquez López and M. E. Vázquez, Chem. Commun., 2022, Advance Article , DOI: 10.1039/D2CC02874C

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