Issue 56, 2022

Stimuli-responsive prodrug of non-steroidal anti-inflammatory drug diclofenac: self-immolative drug release with turn-on near-infrared fluorescence

Abstract

Reactive oxygen species (ROS)-responsive near infrared (NIR) fluorogenic prodrug DCI-ROS is developed for the self-immolative release of diclofenac (DCF) with turn-on fluorescence. The non-toxic prodrug exhibited turn-on red fluorescence with endogenous ROS in cancer cells and inhibited COX-2 expression in the inflammation-induced macrophage cells. The prodrug strategy thus would be helpful for the controlled fluorogenic delivery of DCF for inflammatory diseases.

Graphical abstract: Stimuli-responsive prodrug of non-steroidal anti-inflammatory drug diclofenac: self-immolative drug release with turn-on near-infrared fluorescence

Supplementary files

Article information

Article type
Communication
Submitted
18 Apr 2022
Accepted
16 Jun 2022
First published
16 Jun 2022

Chem. Commun., 2022,58, 7833-7836

Stimuli-responsive prodrug of non-steroidal anti-inflammatory drug diclofenac: self-immolative drug release with turn-on near-infrared fluorescence

A. Sufian, D. Bhattacherjee, P. Barman, A. Srivastava, R. P. Thummer and K. P. Bhabak, Chem. Commun., 2022, 58, 7833 DOI: 10.1039/D2CC02132C

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