Issue 44, 2022
From the journal:

Chemical Communications

Atomic insight into short helical peptide comprised of consecutive multiple aromatic residues†

Rajkumar Misra, ORCID logo ab   Thangavel Vijayakanth, ORCID logo c   Linda J. W. Shimon ORCID logo d  and  Lihi Adler-Abramovich ORCID logo *a  

* Corresponding authors

a Department of Oral Biology, The Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, The Center for Physics & Chemistry of Living Systems, and the Center for Nanoscience and Nanotechnology, Tel-Aviv University, Israel
E-mail: lihiA@tauex.tau.ac.il

b Dept. of Med. Chem, NIPER Mohali, S.A.S. Nagar, Mohali, 160062, India

c The Shmunis School of Biomedicine and Cancer Research George S. Wise, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

d Department of Chemical Research Support, The Weizmann Institute of Science, Rehovot, Israel

Abstract

The occurrence of sequential multiple aromatic residues in a helical sequence is rare compared to the β-sheet rich structure. Here, using helix promoting α-aminoisobutyric acid (Aib) residues, we unravel atomistic details of the helical secondary structure formation and the super helical assembly of two heptapeptides composed of sequential five and six phenylalanine (Phe) residues.

Graphical abstract: Atomic insight into short helical peptide comprised of consecutive multiple aromatic residues

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Article information

DOI
https://doi.org/10.1039/D2CC01038K
Article type
Communication
Submitted
21 Feb 2022
Accepted
02 May 2022
First published
12 May 2022

Chem. Commun., 2022,58, 6445-6448

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Atomic insight into short helical peptide comprised of consecutive multiple aromatic residues

R. Misra, T. Vijayakanth, L. J. W. Shimon and L. Adler-Abramovich, Chem. Commun., 2022, 58, 6445 DOI: 10.1039/D2CC01038K

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