Issue 16, 2022

A water-soluble iron-porphyrin complex capable of rescuing CO-poisoned red blood cells

Abstract

We describe herein a small-molecule platform that exhibits key properties needed by an antidote for CO poisoning. The design features an iron-porphyrin complex with bulky substituents above and below the macrocyclic plane to provide a hydrophobic pocket for CO binding and to prevent the formation of inactive oxo-bridged dimers. Peripheral charged groups impart water solubility. We demonstrate that the Fe(II) complex of a porphyrin with 2,6-diphenyl-4-sulfophenyl meso substituents can bind CO, stoichiometrically sequester CO from carboxyhemoglobin, and rescue CO-poisoned red blood cells.

Graphical abstract: A water-soluble iron-porphyrin complex capable of rescuing CO-poisoned red blood cells

Supplementary files

Article information

Article type
Communication
Submitted
30 Sep 2021
Accepted
28 Jan 2022
First published
28 Jan 2022

Chem. Commun., 2022,58, 2722-2725

A water-soluble iron-porphyrin complex capable of rescuing CO-poisoned red blood cells

D. G. Droege and T. C. Johnstone, Chem. Commun., 2022, 58, 2722 DOI: 10.1039/D1CC05542A

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