Issue 40, 2021

A dual function electro-optical silicon field-effect transistor molecular sensor

Abstract

We propose and demonstrate an approach that utilizes field-effect transistors (FETs) for the real-time detection of interactions between molecules. In this approach, FET-based sensors utilize two unique functions, high charge sensitivity and high photon responsivity. We use these transistors to detect the changes in molecular charge and photon absorption associated with the binding of antibody and antigen molecules. For comparison with enzyme-linked immunosorbent assay (ELISA), we adopt an ELISA sandwich structure immobilized on the FET surface to detect neutrophil gelatinase-associated lipocalin (NGAL). Using this technique, we detect NGAL quantitatively with a sensitivity of 0.1 pg mL−1 and <1 pg mL−1 based on charge sensing and oxidized TMB absorption detection, respectively. We further show that this platform performs great for diagnostic applications of biosensors.

Graphical abstract: A dual function electro-optical silicon field-effect transistor molecular sensor

Supplementary files

Article information

Article type
Paper
Submitted
20 Jul 2021
Accepted
15 Sep 2021
First published
17 Sep 2021

J. Mater. Chem. C, 2021,9, 14286-14293

A dual function electro-optical silicon field-effect transistor molecular sensor

P. J. B. Laksana, L. Tsai, T. Wei, P. Lan, K. Chang-Liao, M. K. Moodley and C. Chen, J. Mater. Chem. C, 2021, 9, 14286 DOI: 10.1039/D1TC03374C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements