Issue 29, 2021

Bone-adhesive barrier membranes based on alendronate-functionalized poly(2-oxazoline)s


To create a novel generation of barrier membranes with bone-adhesive properties, three-component membranes were successfully developed using a solvent-free approach by combining an occlusive polyester backing layer with a bone-adhesive fibrous gelatin carrier impregnated with calcium-binding alendronate-functionalized poly(2-oxazoline)s (POx-Ale). The mechanical properties of these novel membranes were similar to other commercially available barrier membranes. In contrast, the adhesion of our membranes towards bone was by far superior (i.e. 62-fold) compared to conventional commercially available Bio-Gide® membranes. Moreover, alendronate-functionalized membranes retained their bone-adhesive properties under wet conditions in phosphate-buffered saline (PBS) solutions with and without collagenase. Finally, the in vitro degradation of the membranes was studied by monitoring their weight loss upon immersion in PBS solutions with and without collagenase. The membranes degraded in a sustained manner, which was accelerated by the presence of collagenase due to enzymatic degradation of the carrier. In conclusion, our results show that surface functionalization of barrier membranes with alendronate moieties renders them adhesive to bone. As such, the biomaterials design strategy presented herein opens up new avenues of research on bone-adhesive membranes for guided bone regeneration.

Graphical abstract: Bone-adhesive barrier membranes based on alendronate-functionalized poly(2-oxazoline)s

Supplementary files

Article information

Article type
09 Mar 2021
16 Jun 2021
First published
13 Jul 2021
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2021,9, 5848-5860

Bone-adhesive barrier membranes based on alendronate-functionalized poly(2-oxazoline)s

M. J. Sánchez-Fernández, M. Peerlings, R. P. Félix Lanao, J. C. M. E. Bender, J. C. M. van Hest and S. C. G. Leeuwenburgh, J. Mater. Chem. B, 2021, 9, 5848 DOI: 10.1039/D1TB00502B

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