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Issue 12, 2021
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Recent advances in the design of inorganic and nano-clay particles for the treatment of brain disorders

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Abstract

Inorganic materials, in particular nanoclays and silica nanoparticles, have attracted enormous attention due to their versatile and tuneable properties, making them ideal candidates for a wide range of biomedical applications, such as drug delivery. This review aims at overviewing recent developments of inorganic nanoparticles (like porous or mesoporous silica particles) and different nano-clay materials (like montmorillonite, laponites or halloysite nanotubes) employed for overcoming the blood brain barrier (BBB) in the treatment and therapy of major brain diseases such as Alzheimer's, Parkinson's, glioma or amyotrophic lateral sclerosis. Recent strategies of crossing the BBB through invasive and not invasive administration routes by using different types of nanoparticles compared to nano-clays and inorganic particles are overviewed.

Graphical abstract: Recent advances in the design of inorganic and nano-clay particles for the treatment of brain disorders

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Article information


Submitted
21 Dec 2020
Accepted
25 Jan 2021
First published
25 Jan 2021

J. Mater. Chem. B, 2021,9, 2756-2784
Article type
Review Article

Recent advances in the design of inorganic and nano-clay particles for the treatment of brain disorders

F. Persano, S. Batasheva, G. Fakhrullina, G. Gigli, S. Leporatti and R. Fakhrullin, J. Mater. Chem. B, 2021, 9, 2756
DOI: 10.1039/D0TB02957B

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