Jump to main content
Jump to site search

Issue 26, 2021
Previous Article Next Article

3D printed nitric oxide-releasing poly(acrylic acid)/F127/cellulose nanocrystal hydrogels

Author affiliations

Abstract

Hydrogels have been used as matrices for the topical delivery of nitric oxide (NO) for achieving vasodilation, wound healing and analgesic actions. More recently, supramolecular hydrogels comprised of poly(acrylic acid) (PAA) and micellar Pluronic F127 (F127), prepared by thermal reaction, emerged as a suitable matrix for the incorporation of hydrophilic NO donors, such as S-nitrosoglutathione (GSNO). Herein, we describe an innovative method for the three-dimensional (3D) printing of cellulose nanocrystal (CNC)-containing and semi-interpenetrating PAA/F127 hydrogels by PAA photopolymerization via digital light processing (DLP), in the absence of organic solvents. Scanning electron microscopy showed that, differently from typical porous PAA-based hydrogels, the 3D printed PAA/F127/CNC hydrogels have dense morphology. By using transmission electron microscopy we confirmed for the first time the presence of F127 micelles in the printable resin, and their preservation after the photopolymerization process. The F127 micelles conferred compressive recoverability to the 3D printed PAA/F127/CNC hydrogels, widening their potential applications as soft biomaterials. PAA/F127/CNC hydrogels charged with GSNO are shown to release NO spontaneously upon hydration at initial rates that depend on the GSNO charge and are higher in the presence of CNC. As local NO release may exert cell proliferation action, 3D printed PAA/F127/CNC/GSNO hydrogels may serve as a versatile soft biomaterial for local NO delivery in regenerative medicine and other biomedical applications.

Graphical abstract: 3D printed nitric oxide-releasing poly(acrylic acid)/F127/cellulose nanocrystal hydrogels

Back to tab navigation

Supplementary files

Article information


Submitted
29 Jan 2021
Accepted
28 May 2021
First published
31 May 2021

Soft Matter, 2021,17, 6352-6361
Article type
Paper

3D printed nitric oxide-releasing poly(acrylic acid)/F127/cellulose nanocrystal hydrogels

M. I. Santos, L. C. E. da Silva, M. P. Bomediano, D. M. Catori, M. C. Gonçalves and M. G. de Oliveira, Soft Matter, 2021, 17, 6352 DOI: 10.1039/D1SM00163A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements