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Issue 14, 2021

Modelling the dynamics of vesicle reshaping and scission under osmotic shocks

Author affiliations

Abstract

We study the effects of osmotic shocks on lipid vesicles via coarse-grained molecular dynamics simulations by explicitly considering the solute in the system. We find that depending on their nature (hypo- or hypertonic) such shocks can lead to bursting events or engulfing of external material into inner compartments, among other morphology transformations. We characterize the dynamics of these processes and observe a separation of time scales between the osmotic shock absorption and the shape relaxation. Our work consequently provides an insight into the dynamics of compartmentalization in vesicular systems as a result of osmotic shocks, which can be of interest in the context of early proto-cell development and proto-cell compartmentalisation.

Graphical abstract: Modelling the dynamics of vesicle reshaping and scission under osmotic shocks

Supplementary files

Article information


Submitted
12 Nov 2020
Accepted
10 Feb 2021
First published
16 Feb 2021

This article is Open Access

Soft Matter, 2021,17, 3798-3806
Article type
Paper

Modelling the dynamics of vesicle reshaping and scission under osmotic shocks

C. Vanhille-Campos and A. Šarić, Soft Matter, 2021, 17, 3798 DOI: 10.1039/D0SM02012E

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