Issue 29, 2021

Design and recognition of cucurbituril-secured platinum-bound oligopeptides

Abstract

Platinum terpyridyl complexes, stacked on top of one another and secured as dimers with cucurbit[8]uril (CB[8]) in aqueous medium, were functionalized quantitatively and in situ with a pair of pentapeptides Phe-(Gly)3-Cys by grafting their cysteine residues to the Pt centers. The resulting CB[8]·(Pt·peptide)2 assemblies were used to target secondary hosts CB[7] and CB[8] via their pair of phenylalanine residues, again in situ. A series of well-defined architectures, including a supramolecular “pendant necklace” with hybrid head-to-head and head-to-tail arrangements inside CB[8], were obtained during the self-sorting process after combining only 3 or 4 simple building units.

Graphical abstract: Design and recognition of cucurbituril-secured platinum-bound oligopeptides

Supplementary files

Article information

Article type
Edge Article
Submitted
13 May 2021
Accepted
16 Jun 2021
First published
17 Jun 2021
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2021,12, 9962-9968

Design and recognition of cucurbituril-secured platinum-bound oligopeptides

H. Barbero and E. Masson, Chem. Sci., 2021, 12, 9962 DOI: 10.1039/D1SC02637B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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