Issue 20, 2021

An integrated console for capsule-based, automated organic synthesis


The current laboratory practices of organic synthesis are labor intensive, impose safety and environmental hazards, and hamper the implementation of artificial intelligence guided drug discovery. Using a combination of reagent design, hardware engineering, and a simple operating system we provide an instrument capable of executing complex organic reactions with prepacked capsules. The machine conducts coupling reactions and delivers the purified products with minimal user involvement. Two desirable reaction classes – the synthesis of saturated N-heterocycles and reductive amination – were implemented, along with multi-step sequences that provide drug-like organic molecules in a fully automated manner. We envision that this system will serve as a console for developers to provide synthetic methods as integrated, user-friendly packages for conducting organic synthesis in a safe and convenient fashion.

Graphical abstract: An integrated console for capsule-based, automated organic synthesis

Supplementary files

Article information

Article type
Edge Article
22 Feb 2021
09 Apr 2021
First published
13 Apr 2021
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2021,12, 6977-6982

An integrated console for capsule-based, automated organic synthesis

T. Jiang, S. Bordi, A. E. McMillan, K. Chen, F. Saito, P. L. Nichols, B. M. Wanner and J. W. Bode, Chem. Sci., 2021, 12, 6977 DOI: 10.1039/D1SC01048D

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