Pre-regulation of the planar chirality of pillararenes for preparing discrete chiral nanotubes†
Regulating the chirality of macrocyclic host molecules and supramolecular assemblies is crucial because chirality often plays a role in governing the properties of these systems. Herein, we describe pillararene-based chiral nanotube formation via pre-regulation of the building blocks' chirality, which is different from frequently used post-regulation strategies. The planar chirality of rim-differentiated pillararenes is initially regulated by chiral awakening and further induction/inversion through stepwise achiral external stimuli. The pre-regulated chiral information is well stored in discrete nanotubes by interacting with a per-alkylamino-substituted pillararene. Such pre-regulation is more efficient than post-regulating the chirality of nanotubes.