Bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN alcohol) is the most prominent strained-alkyne scaffold in chemical biology. Described herein is the synthesis of an oxidized analogue – BCN acid – whose facile functionalization via amide bond formation yields more stable derivatives than the classically encountered carbamates.
![Graphical abstract: Bicyclo[6.1.0]nonyne carboxylic acid for the production of stable molecular probes](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D1RA07905K&imageInfo.ImageIdentifier.Year=2021)
T. Rady, M. Mosser, M. Nothisen, S. Erb, I. Dovgan, S. Cianférani, A. Wagner and G. Chaubet, RSC Adv., 2021, 11, 36777 DOI: 10.1039/D1RA07905K
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