Issue 57, 2021

One-pot analysis of enantiomeric excess of free amino acids by electrospray ionization mass spectrometry

Abstract

An electrospray ionization mass spectrometric method for the simultaneous analysis of the enantiomeric excess of free amino acids, without chromatographic separation, was demonstrated using a quasi-racemic mixture of deuterium-labelled and unlabelled chiral copper(II) complexes. This convenient method enables the simultaneous high-sensitivity determination of the enantiomeric excess of 12 amino acids.

Graphical abstract: One-pot analysis of enantiomeric excess of free amino acids by electrospray ionization mass spectrometry

Supplementary files

Article information

Article type
Paper
Submitted
31 Aug 2021
Accepted
03 Nov 2021
First published
10 Nov 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 36237-36241

One-pot analysis of enantiomeric excess of free amino acids by electrospray ionization mass spectrometry

T. Nakakoji, H. Sato, D. Ono, H. Miyake, E. Mieda, S. Shinoda, H. Tsukube, H. Kawasaki, R. Arakawa and M. Shizuma, RSC Adv., 2021, 11, 36237 DOI: 10.1039/D1RA06542D

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