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Issue 29, 2021, Issue in Progress
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Rare bioparticle detection via deep metric learning

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Abstract

Recent deep neural networks have shown superb performance in analyzing bioimages for disease diagnosis and bioparticle classification. Conventional deep neural networks use simple classifiers such as SoftMax to obtain highly accurate results. However, they have limitations in many practical applications that require both low false alarm rate and high recovery rate, e.g., rare bioparticle detection, in which the representative image data is hard to collect, the training data is imbalanced, and the input images in inference time could be different from the training images. Deep metric learning offers a better generatability by using distance information to model the similarity of the images and learning function maps from image pixels to a latent space, playing a vital role in rare object detection. In this paper, we propose a robust model based on a deep metric neural network for rare bioparticle (Cryptosporidium or Giardia) detection in drinking water. Experimental results showed that the deep metric neural network achieved a high accuracy of 99.86% in classification, 98.89% in precision rate, 99.16% in recall rate and zero false alarm rate. The reported model empowers imaging flow cytometry with capabilities of biomedical diagnosis, environmental monitoring, and other biosensing applications.

Graphical abstract: Rare bioparticle detection via deep metric learning

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Article information


Submitted
13 Apr 2021
Accepted
07 May 2021
First published
13 May 2021

This article is Open Access

RSC Adv., 2021,11, 17603-17610
Article type
Paper

Rare bioparticle detection via deep metric learning

S. Luo, Y. Shi, L. K. Chin, Y. Zhang, B. Wen, Y. Sun, B. T. T. Nguyen, G. Chierchia, H. Talbot, T. Bourouina, X. Jiang and A. Liu, RSC Adv., 2021, 11, 17603
DOI: 10.1039/D1RA02869C

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