Issue 35, 2021, Issue in Progress

Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the 5mCG base pair

Abstract

We herein demonstrated for the first time the direct recognition of duplex DNA bearing the 5-methyl-2′-deoxycytosine and 2′-deoxyguanosine base pair by triplex DNA formation. Triplex-forming oligonucleotides contained the novel artificial nucleoside analogues 2-amino-2′-deoxy-nebularine derivatives, and their molecular design, synthesis, and functional evaluation are described.

Graphical abstract: Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the 5mCG base pair

Supplementary files

Article information

Article type
Paper
Submitted
12 Apr 2021
Accepted
08 Jun 2021
First published
16 Jun 2021
This article is Open Access
Creative Commons BY license

RSC Adv., 2021,11, 21390-21396

Design and synthesis of purine nucleoside analogues for the formation of stable anti-parallel-type triplex DNA with duplex DNA bearing the 5mCG base pair

R. Notomi, L. Wang, S. Sasaki and Y. Taniguchi, RSC Adv., 2021, 11, 21390 DOI: 10.1039/D1RA02831F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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