Issue 22, 2021, Issue in Progress
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RSC Advances

Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols†

Ke Wang, ORCID logo a   Hao Chen,a   Xinyan Dai,a   Xupeng Huanga  and  Zhiqiang Feng*a  

* Corresponding authors

a Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, P R China
E-mail: fengzhq@imm.ac.cn

Abstract

Palladium-catalyzed 2-substituted quinazolin-4(3H)-one formation from readily available o-nitrobenzamides and alcohols using hydrogen transfer is described. Various quinazolin-4(3H)-ones were obtained in good to high yields. The cascade reaction including alcohol oxidation, nitro reduction, condensation, and dehydrogenation occurs without any added reducing or oxidizing agent.

Graphical abstract: Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols

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Article information

DOI
https://doi.org/10.1039/D1RA01755A
Article type
Paper
Submitted
05 Mar 2021
Accepted
31 Mar 2021
First published
07 Apr 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 13119-13123

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Palladium-catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones from o-nitrobenzamide and alcohols

K. Wang, H. Chen, X. Dai, X. Huang and Z. Feng, RSC Adv., 2021, 11, 13119 DOI: 10.1039/D1RA01755A

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