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Issue 16, 2021, Issue in Progress

Polymer-supported synthesis of N-substituted anthranilates as the building blocks for preparation of N-arylated 3-hydroxyquinolin-4(1H)-ones

Author affiliations

Abstract

Fast and simple access to N-arylated 3-hydroxyquinolin-4(1H)-ones starting from easily available 1-methyl-2-iodoterephthalate and variously substituted anilines is presented. N-Alkylated anthranilic acid derivatives represent important intermediates. They can be advantageously prepared by solid-phase synthesis, by Buchwald–Hartwig amination or reductive amination with wide substrate scope and with excellent crude purities.

Graphical abstract: Polymer-supported synthesis of N-substituted anthranilates as the building blocks for preparation of N-arylated 3-hydroxyquinolin-4(1H)-ones

Supplementary files

Article information


Submitted
17 Feb 2021
Accepted
19 Feb 2021
First published
02 Mar 2021

This article is Open Access

RSC Adv., 2021,11, 9362-9365
Article type
Paper

Polymer-supported synthesis of N-substituted anthranilates as the building blocks for preparation of N-arylated 3-hydroxyquinolin-4(1H)-ones

S. Krajčovičová, J. Hlaváč and K. Vychodilová, RSC Adv., 2021, 11, 9362 DOI: 10.1039/D1RA01308D

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