Issue 21, 2021

Small functionalized iron oxide nanoparticles for dual brain magnetic resonance imaging and fluorescence imaging

Abstract

The diagnosis of brain diseases is the first key step in effective treatment. In vivo imaging tracers that effectively cross the blood–brain barrier (BBB) and reach areas of brain dysregulation is one focus of accurate diagnosis. Here, our main objective was to develop an iron-based nanoparticle for dual brain magnetic resonance imaging (MRI) and fluorescence imaging studies. Small sized iron oxide nanoparticles (SIONs) were prepared by a solvothermal method. Angiopep-2 was covalently connected to the surface of SIONs to enhance penetration of the BBB. The photosensitizer (chlorin e6, Ce6) was modified on the surface of SIONs to enhance fluorescence imaging to corroborate MRI results. We found that the resultant SIONs@ANG/Ce6/PEG displayed good biocompatibility and excellent MRI and fluorescence detection. Moreover, dual-modal MR/fluorescence imaging demonstrated that SIONs@ANG/Ce6/PEG had high sensitivity and accuracy in imaging of mouse with brain tumors. This work provides a strategy to design dual-modal contrast agents for diagnosis of brain disease.

Graphical abstract: Small functionalized iron oxide nanoparticles for dual brain magnetic resonance imaging and fluorescence imaging

Supplementary files

Article information

Article type
Paper
Submitted
10 Dec 2020
Accepted
28 Mar 2021
First published
06 Apr 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 12867-12875

Small functionalized iron oxide nanoparticles for dual brain magnetic resonance imaging and fluorescence imaging

R. Wei, Y. Liu, J. Gao, V. W. Yong and M. Xue, RSC Adv., 2021, 11, 12867 DOI: 10.1039/D0RA10392F

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements