Issue 3, 2021

Amino acid ester-coupled caffeoylquinic acid derivatives as potential hypolipidemic agents: synthesis and biological evaluation

Abstract

Pandanus tectorius (L.) Parkins. (PTPs) is rich in caffeoylquinic acids and amino acids, especially some essential amino acids, such as valine, phenylalanine, and so forth. A series of novel amino acid ester-coupled caffeoylquinic acid derivatives have been designed and synthesized. Biological evaluation suggested that some amino acid ester-coupled derivatives exhibited varying degrees of lipid-lowering effects on oleic acid-elicited lipid accumulation in HepG2 liver cells. Particularly, derivatives 6c, 6d, 6e and 6f exhibited comparable potential lipid-lowering effect with the positive control simvastatin and chlorogenic acid. Further studies on the mechanism of 6c, 6d, 6e and 6f revealed that the lipid-lowering effects were related to their regulation of TG levels and mRNA levels of lipometabolic-modulating genes, and merit further investigation.

Graphical abstract: Amino acid ester-coupled caffeoylquinic acid derivatives as potential hypolipidemic agents: synthesis and biological evaluation

Supplementary files

Article information

Article type
Paper
Submitted
12 Nov 2020
Accepted
21 Dec 2020
First published
05 Jan 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 1654-1661

Amino acid ester-coupled caffeoylquinic acid derivatives as potential hypolipidemic agents: synthesis and biological evaluation

X. Zhang, D. Liu, H. Shang, Y. Jia, X. Xu, Y. Tian and P. Guo, RSC Adv., 2021, 11, 1654 DOI: 10.1039/D0RA09621K

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