Selective release of a potent anticancer agent from a supramolecular hydrogel using green light

Johannes Karcher; Susanne Kirchner; Anna-Lena Leistner; Christian Hald; Philipp Geng; Tobias Bantle; Peter Gödtel; Juliana Pfeifer; Zbigniew L. Pianowski

doi:10.1039/D0RA08893E

Selective release of a potent anticancer agent from a supramolecular hydrogel using green light†

Johannes Karcher,^a Susanne Kirchner,^a Anna-Lena Leistner,^a Christian Hald,^a Philipp Geng,^a Tobias Bantle,^a Peter Gödtel,^a Juliana Pfeifer^b and Zbigniew L. Pianowski

*^ac

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* Corresponding authors

^a Institut für Organische Chemie, Karlsruher Institut für Technologie, Campus Süd, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany
E-mail: pianowski@kit.edu

^b Institut für Funktionelle Grenzflächen IFG, Karlsruher Institut für Technologie, Campus Nord, Hermann-von-Helmholtz Platz 1, 76344 Eggenstein-Leopoldshafen, Germany

^c Institute of Biological and Chemical Systems – FMS, Karlsruher Institut für Technologie, Campus Nord, Hermann-von-Helmholtz Platz 1, 76344 Eggenstein-Leopoldshafen, Germany

Abstract

Light-triggered drug release from hydrogels is a promising method to improve efficiency of antitumor treatment, as an alternative to existing photodynamic therapies. Here we report a photochromic supramolecular low-MW hydrogel that can quickly and selectively release a physically encapsulated potent anticancer agent upon green light irradiation under physiological conditions.

This article is part of the themed collection: Emerging Investigators Series

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DOI: https://doi.org/10.1039/D0RA08893E
Article type: Paper
Submitted: 19 Oct 2020
Accepted: 17 Feb 2021
First published: 24 Feb 2021
This article is Open Access

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RSC Adv., 2021,11, 8546-8551

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Selective release of a potent anticancer agent from a supramolecular hydrogel using green light

J. Karcher, S. Kirchner, A. Leistner, C. Hald, P. Geng, T. Bantle, P. Gödtel, J. Pfeifer and Z. L. Pianowski, RSC Adv., 2021, 11, 8546 DOI: 10.1039/D0RA08893E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Selective release of a potent anticancer agent from a supramolecular hydrogel using green light†

Abstract

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Selective release of a potent anticancer agent from a supramolecular hydrogel using green light

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