Issue 19, 2021

Synthetic applications of α,α-difluoroarylacetic acids and salts via decarboxylative functionalization

Abstract

α,α-Difluoroarylacetic acids are stable, inexpensive and readily available building blocks, which have been recently utilized as synthons to access various difluoromethylated aryl motifs via decarboxylative functionalization, such as alkylation, allylation, alkynylation, arylation, fluorination and the formation of carbon–heteroatom (O, S) bonds. In this review, we systematically summarize the decarboxylative functionalization of α,α-difluoroarylacetic acids and salts, and their mechanisms are also discussed.

Graphical abstract: Synthetic applications of α,α-difluoroarylacetic acids and salts via decarboxylative functionalization

Article information

Article type
Review Article
Submitted
21 May 2021
Accepted
27 Jun 2021
First published
08 Jul 2021

Org. Chem. Front., 2021,8, 5516-5530

Synthetic applications of α,α-difluoroarylacetic acids and salts via decarboxylative functionalization

W. Mei, Y. Kong and G. Yan, Org. Chem. Front., 2021, 8, 5516 DOI: 10.1039/D1QO00775K

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