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Zirconium-Hydride-Catalyzed Transfer Hydrogenation of Quinoline and Indole with Ammonia Borane

Abstract

Herein, by applying zirconium-hydride complex as the catalyst, the transfer hydrogenation of quinoline and indole derivatives with ammonia borane as the proton and hydride source is achieved. Up to 94% yields of the corresponding hydrogenated products were obtained with tolerance of various functional groups. Preliminary mechanistic studies revealed a concerted N-H and B-H activation reaction pathway.

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Article information


Submitted
29 Apr 2021
Accepted
09 Jun 2021
First published
10 Jun 2021

Org. Chem. Front., 2021, Accepted Manuscript
Article type
Research Article

Zirconium-Hydride-Catalyzed Transfer Hydrogenation of Quinoline and Indole with Ammonia Borane

X. Cui, W. huang and L. Wu, Org. Chem. Front., 2021, Accepted Manuscript , DOI: 10.1039/D1QO00672J

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