Issue 16, 2021

Rh-Catalyzed oxidative homo-coupling cyclization of 2,3-allenols to conjugated furylenones

Abstract

An unexpected rhodium-catalyzed highly regio- and stereo-selective bimolecular nucleophilic oxyrhodation/insertion/1,4-Rh migration/β-H elimination reaction of 2,3-allenols affording (2,5-dihydrofuran-3-yl)but-2(E)-en-1-one derivatives is reported. Optically active products may be prepared from optically active 2,3-allenols without obvious racemization. The synthetic potentials have been demonstrated.

Graphical abstract: Rh-Catalyzed oxidative homo-coupling cyclization of 2,3-allenols to conjugated furylenones

Supplementary files

Article information

Article type
Research Article
Submitted
22 Apr 2021
Accepted
01 Jun 2021
First published
02 Jun 2021

Org. Chem. Front., 2021,8, 4432-4437

Rh-Catalyzed oxidative homo-coupling cyclization of 2,3-allenols to conjugated furylenones

X. Wu, J. Fan, X. Huang and S. Ma, Org. Chem. Front., 2021, 8, 4432 DOI: 10.1039/D1QO00599E

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